Jones R N, Barry A L, Fuchs P C, Gavan T L, Sommers H M, Gerlach E H
Antimicrob Agents Chemother. 1979 Dec;16(6):823-8. doi: 10.1128/AAC.16.6.823.
The susceptibility of 11,840 clinical bacterial isolates to fortimicin A was determined by agar dilution or broth microdilution methods and compared with their susceptibility to amikacin and gentamicin. In general, the in vitro activity of fortimicin A was essentially the same as that of amikacin. Significant exceptions were the increased effectiveness of fortimicin A against Serratia marcescens and the greater activity of amikacin against Pseudomonas and other nonfermentative gram-negative bacilli. On a weight-for-weight basis, gentamicin showed greater activity than the other two antimicrobial drugs against most species; S. Marcescens was the major exception. However, at concentrations equivalent to achievable nontoxic serum levels, the proportion of isolates inhibited by the three drugs was quite comparable. There were several strains with unusually high resistance to one or more of the tested antibiotics. These usually occurred in one of the six participating institutions and could be traced to specific enzyme-producing or permeability mutants endemic to that particular institution.
采用琼脂稀释法或肉汤微量稀释法测定了11840株临床分离细菌对福提霉素A的敏感性，并将其与对阿米卡星和庆大霉素的敏感性进行比较。总体而言，福提霉素A的体外活性与阿米卡星基本相同。显著的例外是福提霉素A对粘质沙雷氏菌的有效性增加以及阿米卡星对假单胞菌和其他非发酵革兰氏阴性杆菌的活性更强。以重量计，庆大霉素对大多数菌种的活性比其他两种抗菌药物更强；粘质沙雷氏菌是主要例外。然而，在相当于可达到的无毒血清水平的浓度下，三种药物抑制的分离株比例相当。有几株对一种或多种受试抗生素具有异常高耐药性的菌株。这些菌株通常出现在六个参与机构中的一个，并且可以追溯到该特定机构特有的特定产酶或通透性突变体。
