Girolami R L, Stamm J M
J Antibiot (Tokyo). 1977 Jul;30(7):564-70. doi: 10.7164/antibiotics.30.564.
The in vitro antimicrobial activity of fortimicin A, the most active member of the fortimicin complex, was compared with that of amikacin, gentamicin, sagamicin and tobramycin against 352 strains of Enterobacteriaceae and other medically significant organisms. Against most of these organisms fortimicin and amikacin had comparable levels of antimicrobial activity, generally slightly less than that of gentamicin, sagamicin or tobramycin. Fortimicin had relatively weak activity against Pseudomonas aeruginosa strains. Fortimicin shows many of the characteristics of other aminoglycoside antibiotics: (i) improved activity at alkaline pH, (ii) rapid, bactericidal action, (iii) reduced activity with increasing inoculum levels, and (iv) synergistic activity with penicillin against enterococci. The activity of fortimicin was compared to that of gentamicin, tobramycin and amikacin against a group of 95 naturally occurring, antibiotic-resistant Gram-negative bacilli other than Pseudomonas. The organisms were isolated from clinical sources and selected primarily for gentamicin resistance by the sensitivity disc test. Fortimicin showed excellent activity against this group of organisms. At a concentration of 6.2 mcg/ml, fortimicin inhibited the most strains (92.6%) followed by amikacin (90.5%), gentamicin (23.2%) and tobramycin (8.4%).
将福提霉素复合物中活性最强的成员福提霉素A的体外抗菌活性，与丁胺卡那霉素、庆大霉素、紫苏霉素和妥布霉素针对352株肠杆菌科细菌及其他具有重要医学意义的微生物的抗菌活性进行了比较。针对大多数这些微生物，福提霉素和丁胺卡那霉素具有相当的抗菌活性水平，总体上略低于庆大霉素、紫苏霉素或妥布霉素。福提霉素对铜绿假单胞菌菌株的活性相对较弱。福提霉素具有其他氨基糖苷类抗生素的许多特性：（i）在碱性pH值下活性增强；（ii）快速杀菌作用；（iii）随着接种量增加活性降低；（iv）与青霉素对肠球菌具有协同活性。将福提霉素与庆大霉素、妥布霉素和丁胺卡那霉素针对一组95株除假单胞菌外自然产生的耐抗生素革兰氏阴性杆菌的活性进行了比较。这些微生物从临床来源分离得到，主要通过药敏纸片试验选择对庆大霉素耐药的菌株。福提霉素对这组微生物显示出优异的活性。在浓度为6.2 mcg/ml时，福提霉素抑制的菌株最多（92.6%），其次是丁胺卡那霉素（90.5%）、庆大霉素（23.2%）和妥布霉素（8.4%）。
