Gupta A K, Bhargava K P
Pharmazie. 1978 Jul;33(7):430-1. doi: 10.1002/chin.197849226.
4-[4-(3-Substituted-1-acetyloxycarbamido)-benzylidene] amino-1.2.4-triazoles were synthesized and evaluated for anti-inflammatory activity against carrageenin-induced foot paw edema in albino rats. All compounds, with the exception of one, afforded anti-inflammatory activity. Approximate LD50 of all the substituted triazoles was found to be higher than 750 mg/kg. Substitution at the phenyl group attached to N at the position 3 of the carbamide, in general, resulted in increase of anti-edema effect.
合成了4-[4-(3-取代-1-乙酰氧基氨基甲酰基)-亚苄基]氨基-1,2,4-三唑，并对其在白化大鼠中对角叉菜胶诱导的足爪水肿的抗炎活性进行了评估。除一种化合物外，所有化合物均具有抗炎活性。发现所有取代三唑的近似半数致死量均高于750mg/kg。一般来说，在脲的3位与氮相连的苯基上进行取代会导致抗水肿效果增强。
