Pannella A, Gatti A, Lelli R
Arch Sci Med (Torino). 1981 Jan-Mar;138(1):39-52.
A review of the relevant literature is followed by an investigation of the effect of male and female hormones on the onset and growth of 20-methylcholanthrene induced tumours in approximately 15-day-old rats. The results indicated that oestrogens facilitate the onset of tumours in females, and hinder it in males, whereas testosterone provokes tumours in both males and females, contrary to what happens in the adult rat. It is felt that the latter finding can be ascribed to the fact that, since the transformation of oestradiol from testosterone usually takes place at 12 months (Di Prisco et al)., the antagonist effect between hormones of different sex which appears to oppose tumour growth had not yet occurred. This, then could be one of the reasons for carcinogenesis in female rats treated with testosterone, aided by hormonal stimulus of cell glycolysis.
在对相关文献进行综述之后，研究了雄性和雌性激素对约15日龄大鼠中20-甲基胆蒽诱导肿瘤的发生和生长的影响。结果表明，雌激素促进雌性大鼠肿瘤的发生，而抑制雄性大鼠肿瘤的发生，而睾酮则在雄性和雌性大鼠中都诱发肿瘤，这与成年大鼠的情况相反。人们认为，后一发现可归因于这样一个事实，即由于睾酮向雌二醇的转化通常在12个月时发生（迪·普里斯科等人），不同性别的激素之间似乎对抗肿瘤生长的拮抗作用尚未出现。那么，这可能是用睾酮治疗的雌性大鼠发生癌变的原因之一，细胞糖酵解的激素刺激对此起到了辅助作用。
