Urtasun R C, Band P, Chapman J D, Rabin H R, Wilson A F, Fryer C G
Radiology. 1977 Mar;122(3):801-4. doi: 10.1148/122.3.801.
RO-07-0582 toxicity studies were performed in 12 patients for a total of 16 assays. Single and multifraction dose schedules were used, and drug concentrations in solid tumor tissue, cerebrospinal fluid, and blood (at 14 to 24 hr.) were established. A severe peripheral neuropathy occurred in 1 patient on the multifraction regimen when the total dosage reached 24 g. Drug absorption and concentration in the blood do not significantly differ from that of metronidazole. Maximum blood levels were reached at from 2 to 4 hr., and several days subsequent to administration had stabilized to levels only slightly above control levels.
RO - 07 - 0582毒性研究在12名患者中进行，共进行了16次试验。采用了单次和多剂量给药方案，并测定了实体瘤组织、脑脊液和血液（给药后14至24小时）中的药物浓度。1例接受多剂量方案的患者在总剂量达到24克时出现了严重的周围神经病变。该药物的血液吸收和浓度与甲硝唑无显著差异。给药后2至4小时达到最高血药浓度，给药几天后血药浓度稳定在仅略高于对照水平。
