Kal'nova N Iu, Pal'mina N P
Biokhimiia. 1980 Sep;45(9):1646-53.
Changes in the phospholipid content and the antioxidant activity of the lipid fractions of erythrocytes in patients with different mammalian gland tumours, e. g. fibroadenoma, fibrocystic mastopathy and carcinomas, before and after radiotherapy were studied. It was found that the content of individual phospholipid fractions and their physico-chemical properties vary depending on the type of the tumour. Nevertheless in all cases studied the sphingomyelin content in the erythrocytes at early stages of malignancy is increased, with a maximum exceeding ther normal level 2-fold. Changes in the content of other phospholipids depend on the degree of malignancy and are especially well-pronounced in the neoplasm and at early stages of neogenesis. The phosphatidyl ethanolamine and phosphatidyl serine content in the erythrocytes in fibro-cystic mastopathy is decreased, while that of lysophosphatidyl choline is increased (more than 3-fold). The phosphatidyl choline content is considerably increased in fibroadenoma and is decreased in fibro-cystic mastopathy and carcinomas with a diameter of less than 2 cm. The antioxidant activity of the erythrocyte lipids significantly exceeds the normal level in benign tumours of the mammalian gland and at early stages of neogenesis. Further malignancy is accompanied by a decrease of the antioxidant activity of erythrocytes below the normal level and by an appearance of phosphatidyl inositol in the phospholipid fraction.
研究了不同哺乳动物腺肿瘤（如纤维腺瘤、纤维囊性乳腺病和癌）患者放疗前后红细胞脂质部分的磷脂含量和抗氧化活性变化。发现各个磷脂部分的含量及其物理化学性质因肿瘤类型而异。然而，在所研究的所有病例中，恶性肿瘤早期红细胞中的鞘磷脂含量增加，最高超过正常水平两倍。其他磷脂含量的变化取决于恶性程度，在肿瘤和新生早期尤为明显。纤维囊性乳腺病患者红细胞中的磷脂酰乙醇胺和磷脂酰丝氨酸含量降低，而溶血磷脂酰胆碱含量增加（超过3倍）。纤维腺瘤中磷脂酰胆碱含量显著增加，纤维囊性乳腺病和直径小于2 cm的癌中则降低。哺乳动物腺良性肿瘤和新生早期红细胞脂质的抗氧化活性显著超过正常水平。进一步的恶性肿瘤伴随着红细胞抗氧化活性低于正常水平以及磷脂部分中磷脂酰肌醇的出现。
