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1
Theophylline does not affect morphine inhibition of the isolated vas deferens.茶碱不影响吗啡对离体输精管的抑制作用。
Br J Pharmacol. 1981 Jul;73(3):787-9. doi: 10.1111/j.1476-5381.1981.tb16816.x.
2
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.4-氨基吡啶对离体输精管的作用及其对腺苷、吗啡、去甲肾上腺素和γ-氨基丁酸抑制特性的影响。
Br J Pharmacol. 1981 Jul;73(3):791-6. doi: 10.1111/j.1476-5381.1981.tb16817.x.
3
Partial agonistic action of morphine in the rat vas deferens.吗啡在大鼠输精管中的部分激动作用。
Jpn J Pharmacol. 1981 Dec;31(6):905-9. doi: 10.1254/jjp.31.905.
4
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The effect of chronic morphine treatment of excitatory junction potentials in the mouse vas deferens.慢性吗啡治疗对小鼠输精管兴奋性接头电位的影响。
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Antagonism of presynaptic adenosine receptors by theophylline 9-beta-D-riboside and 8-phenyltheophylline.茶碱9-β-D-核糖苷和8-苯基茶碱对突触前腺苷受体的拮抗作用。
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A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.吗啡敏感型神经效应器连接的一个新实例：小鼠输精管中的肾上腺素能传递。
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10
Effects of morphine on electrically evoked contractions of the vas deferens in two congeneric rodent species differing in sperm competition intensity.吗啡对两种在精子竞争强度上存在差异的同属啮齿动物物种输精管电诱发收缩的影响。
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The effects of morphine and methionine-enkephalin on the release of purines from cerebral cortex slices of rats and mice.吗啡和甲硫氨酸脑啡肽对大鼠和小鼠大脑皮层切片中嘌呤释放的影响。
Br J Pharmacol. 1981 Sep;74(1):171-6. doi: 10.1111/j.1476-5381.1981.tb09970.x.
2
Purine receptors in the rat anococcygeus muscle.大鼠肛尾肌中的嘌呤受体。
J Physiol. 1983 Feb;335:591-608. doi: 10.1113/jphysiol.1983.sp014553.

本文引用的文献

1
Morphine enhances adenosine release from the in vivo rat cerebral cortex.吗啡可增强大鼠大脑皮质在体腺苷的释放。
Eur J Pharmacol. 1980 Jul 11;65(1):97-100. doi: 10.1016/0014-2999(80)90215-0.
2
Blockade of striatal neurone responses to morphine by aminophylline: evidence for adenosine mediation of opiate action.氨茶碱对纹状体神经元吗啡反应的阻断作用：腺苷介导阿片类药物作用的证据。
Br J Pharmacol. 1980 May;69(1):131-7. doi: 10.1111/j.1476-5381.1980.tb10892.x.
3
A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.吗啡敏感型神经效应器连接的一个新实例：小鼠输精管中的肾上腺素能传递。
Br J Pharmacol. 1972 Dec;46(4):764-6. doi: 10.1111/j.1476-5381.1972.tb06901.x.
4
The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat.腺苷对大鼠膈神经递质释放的影响。
J Physiol. 1972 Aug;224(3):629-45. doi: 10.1113/jphysiol.1972.sp009916.
5
Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline.腺苷、腺嘌呤核苷酸和吗啡对胆碱能神经乙酰胆碱释放的抑制作用：茶碱的拮抗作用。
J Pharmacol Exp Ther. 1976 May;197(2):379-90.
6
Comparative effects of opiate agonists methadone, levorphanol, and their isomers on the release of cortical ACh in vivo and in vitro.阿片类激动剂美沙酮、左啡诺及其异构体对体内和体外皮质乙酰胆碱释放的比较作用。
Can J Physiol Pharmacol. 1975 Aug;53(4):540-8. doi: 10.1139/y75-076.
7
The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine.腺苷及相关核苷酸对乙酰胆碱释放的抑制作用。
Neuroscience. 1976;1(5):391-8. doi: 10.1016/0306-4522(76)90132-9.
8
The effects of morphine on the release of noradrenaline from the mouse vas deferens.吗啡对小鼠输精管去甲肾上腺素释放的影响。
Br J Pharmacol. 1976 Aug;57(4):551-7. doi: 10.1111/j.1476-5381.1976.tb10384.x.
9
Morphine increases depolarization induced purine release from rat cortical slices.吗啡增加去极化诱导的大鼠皮质切片中嘌呤的释放。
Acta Physiol Scand. 1978 Dec;104(4):502-4. doi: 10.1111/j.1748-1716.1978.tb06308.x.
10
Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium.甲基黄嘌呤和钙对吗啡作用于脑乙酰胆碱释放的拮抗作用。
Eur J Pharmacol. 1978 Jun 1;49(3):309-12. doi: 10.1016/0014-2999(78)90108-5.

茶碱不影响吗啡对离体输精管的抑制作用。

Theophylline does not affect morphine inhibition of the isolated vas deferens.

作者信息

Stone T W

出版信息

Br J Pharmacol. 1981 Jul;73(3):787-9. doi: 10.1111/j.1476-5381.1981.tb16816.x.

DOI:10.1111/j.1476-5381.1981.tb16816.x
PMID:7248667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071687/
Abstract

1 Adenosine and morphine both produced an inhibition of the electrically-evoked twitch of the isolated superfused vas deferens of the mouse. 2 Theophylline, 10 or 100 muM, reduced the inhibitory action of adenosine but did not change inhibition by morphine. 3 It is suggested that adenosine release is not a necessary prerequisite for morphine inhibition of transmitter release. It is also suggested that the involvement of adenosine may follow activation only by opiate mu-receptors.

摘要
  1. 腺苷和吗啡均可抑制小鼠离体灌流输精管的电诱发抽搐。2. 10或100μM的茶碱可减弱腺苷的抑制作用，但不改变吗啡的抑制作用。3. 提示腺苷释放并非吗啡抑制递质释放的必要前提。还提示腺苷的参与可能仅在阿片μ受体激活后发生。