茶碱不影响吗啡对离体输精管的抑制作用。
Theophylline does not affect morphine inhibition of the isolated vas deferens.
作者信息
Stone T W
出版信息
Br J Pharmacol. 1981 Jul;73(3):787-9. doi: 10.1111/j.1476-5381.1981.tb16816.x.
Abstract
1 Adenosine and morphine both produced an inhibition of the electrically-evoked twitch of the isolated superfused vas deferens of the mouse. 2 Theophylline, 10 or 100 muM, reduced the inhibitory action of adenosine but did not change inhibition by morphine. 3 It is suggested that adenosine release is not a necessary prerequisite for morphine inhibition of transmitter release. It is also suggested that the involvement of adenosine may follow activation only by opiate mu-receptors.
摘要
- 腺苷和吗啡均可抑制小鼠离体灌流输精管的电诱发抽搐。2. 10或100μM的茶碱可减弱腺苷的抑制作用，但不改变吗啡的抑制作用。3. 提示腺苷释放并非吗啡抑制递质释放的必要前提。还提示腺苷的参与可能仅在阿片μ受体激活后发生。
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