McNeely B, Owen D A, Pezim M
Department of Pathology, University of British Columbia, Vancouver General Hospital, Canada.
Am J Clin Pathol. 1992 Jul;98(1):112-6. doi: 10.1093/ajcp/98.1.112.
A 50-year-old man who had chronic ulcerative colitis with dysplasia and two synchronous carcinomas had a total colectomy. Microscopic examination of the resected specimen revealed multiple microcarcinoids that were all smaller than 2 mm in diameter and not visible with gross examination. Histologic examination revealed that they were similar to microcarcinoids of the stomach encountered in patients with pernicious anemia. In this patient, however, there was no associated endocrine cell hyperplasia in the overlying mucosa, and the carcinoids may have arisen from dysplastic stem cells in the colonic crypts.
一名50岁男性，患有慢性溃疡性结肠炎伴发育异常及两个同时性癌，接受了全结肠切除术。对切除标本的显微镜检查发现多个微类癌，其直径均小于2mm，肉眼检查不可见。组织学检查显示，它们与恶性贫血患者胃中的微类癌相似。然而，在该患者中，覆盖黏膜中没有相关的内分泌细胞增生，类癌可能起源于结肠隐窝中发育异常的干细胞。
