Tas Faruk, Kilic Leyla, Duranyildiz Derya
Institute of Oncology, University of Istanbul, Capa, 34390, Istanbul, Turkey,
Tumour Biol. 2014 Jun;35(6):5985-92. doi: 10.1007/s13277-014-1793-4. Epub 2014 Mar 5.
Activated coagulation and fibrinolytic system in cancer patients is associated with tumor stroma formation and metastasis in different cancer types. The aim of this study is to explore the correlation of blood coagulation assays for various clinicopathologic factors in breast cancer patients. A total of 123 female breast cancer patients were enrolled into the study. All the patients were treatment naïve. Pretreatment blood coagulation tests including PT, APTT, PTA, INR, D-dimer, fibrinogen levels, and platelet counts were evaluated. Median age of diagnosis was 51 years old (range 26-82). Twenty-two percent of the group consisted of metastatic breast cancer patients. The plasma level of all coagulation tests revealed statistically significant difference between patient and control group except for PT (p<0.001 for all variables except for PT; p=0.08). Elderly age (>50 years) was associated with higher D-dimer levels (p=0.003). Metastatic patients exhibited significantly higher D-dimer values when compared with early breast cancer patients (p=0.049). Advanced tumor stage (T3 and T4) was associated with higher INR (p=0.05) and lower PTA (p=0.025). In conclusion, coagulation tests show significant differences in patients with breast cancer.
癌症患者体内激活的凝血和纤溶系统与不同癌症类型的肿瘤基质形成和转移相关。本研究旨在探讨乳腺癌患者各种临床病理因素与凝血检测之间的相关性。共有123名女性乳腺癌患者纳入本研究。所有患者均未接受过治疗。评估了包括PT、APTT、PTA、INR、D-二聚体、纤维蛋白原水平和血小板计数在内的治疗前凝血检测指标。诊断时的中位年龄为51岁（范围26 - 82岁）。该组中22%为转移性乳腺癌患者。除PT外，所有凝血检测的血浆水平在患者组和对照组之间均显示出统计学上的显著差异（除PT外，所有变量p<0.001；p = 0.08）。老年（>50岁）与较高的D-二聚体水平相关（p = 0.003）。与早期乳腺癌患者相比，转移性患者的D-二聚体值显著更高（p = 0.049）。肿瘤晚期（T3和T4）与较高的INR（p = 0.05）和较低的PTA（p = 0.025）相关。总之，凝血检测在乳腺癌患者中显示出显著差异。
