Gengozian N, Annostby D
Clin Exp Immunol. 1981 Jan;43(1):128-34.
Interspecies immunization of marmosets with platelets leads to an acute thrombocytopenia which appears to be immunologically mediated. The thrombocytopenia is preceded by the formation of antibodies to the donor platelet antigen and deposition of IgG on the host's platelets. Examination of sera obtained from these animals during the course of the disease has revealed the presence of antibodies towards autologous and host-type platelets. Autologous antibody was found when thrombocytopenia was severe; upon platelet recovery, this antibody was absent or reduced in titre. This in vivo absorption of host-specific (autologous) antibody led to detection in the serum of antibodies reactive to other members of the host species. The presence of such host-type antibodies appeared to be related to the intensity of antigenic stimulation, the amount of antibody formed and the degree of thrombocytopenia. Deposition of IgG on the host's platelets coincided with the appearance of the anti-host antibodies; whether the IgG detected on the host's platelets is exclusively cross-reactive antibody or includes also an immune complex is not yet known. Finally, the data have identified potential immunogenetic differences among members of two marmoset species with respect to platelet antigens.
用血小板对狨猴进行种间免疫会导致急性血小板减少症，这似乎是由免疫介导的。血小板减少症之前会出现针对供体血小板抗原的抗体形成以及IgG在宿主血小板上的沉积。在疾病过程中对这些动物血清的检测发现了针对自体和宿主类型血小板的抗体。当血小板减少症严重时发现了自体抗体；血小板恢复后，这种抗体消失或滴度降低。宿主特异性（自体）抗体的这种体内吸收导致在血清中检测到对宿主物种其他成员有反应的抗体。这种宿主类型抗体的存在似乎与抗原刺激的强度、形成的抗体量以及血小板减少的程度有关。IgG在宿主血小板上的沉积与抗宿主抗体的出现同时发生；在宿主血小板上检测到的IgG是仅为交叉反应性抗体还是也包括免疫复合物尚不清楚。最后，这些数据确定了两种狨猴物种成员在血小板抗原方面潜在的免疫遗传差异。
