Iyengar S S
Comput Programs Biomed. 1980 Dec;12(2-3):183-90. doi: 10.1016/0010-468x(80)90064-1.
The distribution of breaks along The DNA strand in hydrodynamic shearing is unknown, and there is no real-world experiment which could directly determine this distribution. This paper presents an extension of the simulation model for hydrodynamic shearing of DNA reported in [1,2]. An empirical model is presented showing a good linear relationship between LAMBDA * and number of fragments from each original strand. The average strand length is directly proportional to the number of fragments per strand. The traditional assumption of uniform random breaks along the DNA strand is supported by this model.
在流体动力学剪切过程中，DNA链上断裂的分布情况尚不清楚，并且没有实际实验能够直接确定这种分布。本文介绍了文献[1,2]中报道的DNA流体动力学剪切模拟模型的扩展。提出了一个经验模型，该模型显示LAMBDA *与每条原始链的片段数之间存在良好的线性关系。平均链长与每条链的片段数成正比。该模型支持了沿DNA链均匀随机断裂的传统假设。
