Juriloff D M
Dev Pharmacol Ther. 1981;2(1):17-31.
Administration of thyroxin in midgestation has been reported to prevent spontaneous cleft lip in term fetuses of genetically predisposed mice. Attempts to repeat this finding have given ambiguous results. The experiment was therefore repeated using CL/Fr and A/HeJ mice, and various thyroxin dosages. The embryos were examined on days 13 and 14, earlier in gestation than in previous studies. The usual complement of cleft-lip embryos, 21% in CL/Fr and 10% in A/HeJ, was present, but they were often dead. At all dosages of thyroxin that caused embryonic mortality, differential mortality of cleft-lip embryos at term after thyroxin treatment is thus due to their increased mortality, not to prevention of the lip defect.
据报道，在妊娠中期给予甲状腺素可预防基因易患性小鼠足月胎儿的自发性唇裂。重复这一发现的尝试得到了不明确的结果。因此，使用CL/Fr和A/HeJ小鼠以及各种甲状腺素剂量重复了该实验。在妊娠第13天和第14天对胚胎进行检查，比之前的研究更早。出现了通常比例的唇裂胚胎，CL/Fr中为21%，A/HeJ中为10%，但它们往往已经死亡。在所有导致胚胎死亡的甲状腺素剂量下，甲状腺素治疗后足月唇裂胚胎的差异死亡率是由于其死亡率增加，而不是唇裂缺陷得到了预防。
