Negoro H, Akaishi T
Endocrinol Jpn. 1981 Feb;28(1):37-43. doi: 10.1507/endocrj1954.28.37.
Extracellular recordings of action potentials were made and their firing rates were determined from 345 paraventricular neurosecretory cells in ovariectomized rats with or without estrogen treatment. And the effect of anterior or posterior deafferentation of the hypothalamus on the firing rates was studied. In both non-treated and estrogen-treated rats the anterior deafferentation reduced the firing rates significantly (P less than 0.05 in the non-treated rats and P less than 0.01 in the estrogen-treated rats), while the posterior deafferentiation did not change the firing rates significantly. Comparisons between firing rates in estrogen-treated rats and those in non-treated ones revealed what neurosecretory neurones with intact afferent connections and with damaged posterior connections showed a facilitatory response to estrogen but that the neurones with damaged anterior connections failed to show the response. The frequency distribution of the firing rates in each of the experimental groups showed an exponential form. In conclusion, these findings suggest that the extrahypothalmic inputs from the rostral brain regions are important factors in the maintenance of the basal activity of the paraventricular neurosecretory cells. It is also indicated that estrogen stimulates the neurosecretory cell activity indirectly via afferent inputs from the rostral cerebral structures.
在去卵巢大鼠中，无论是否接受雌激素治疗，均对345个室旁神经分泌细胞进行动作电位的细胞外记录，并测定其放电频率。同时研究下丘脑前侧或后侧传入神经切断对放电频率的影响。在未治疗和雌激素治疗的大鼠中，前侧传入神经切断均显著降低了放电频率（未治疗大鼠中P<0.05，雌激素治疗大鼠中P<0.01），而后侧传入神经切断则未显著改变放电频率。对雌激素治疗大鼠和未治疗大鼠的放电频率进行比较发现，传入连接完整且后侧连接受损的神经分泌神经元对雌激素表现出促进反应，而前侧连接受损的神经元则未表现出该反应。每个实验组的放电频率分布呈指数形式。总之，这些发现表明，来自脑前部区域的下丘脑外输入是维持室旁神经分泌细胞基础活动的重要因素。这也表明，雌激素通过来自脑前部结构的传入输入间接刺激神经分泌细胞的活动。
