Netto C A, Izquierdo I
Psychoneuroendocrinology. 1985;10(2):159-63. doi: 10.1016/0306-4530(85)90053-8.
The amnestic effect of immediate post-training transcorneal electroconvulsive shock ECS (15.0 mA, 60 Hz, 2 sec) on step-down inhibitory avoidance learning (0.5 mA, 60 Hz training footshock) was studied in intact rats and in rats submitted to bilateral surgical transection of the dorsal fornix, to anterior or posterior hypothalamic deafferentation, and in sham-operated animals. Animals were tested for retention 24 hr after training. The amnestic effect of ECS was observed in all groups except in the one with the posterior hypothalamic lesion. Fornix-lesioned animals showed a moderate retention deficit which was considerably worsened by the ECS treatment. The results indicate that the amnestic effect of ECS requires integrity of posterior hypothalamic pathways. One possibility is that the amnestic effect of ECS may be mediated by posterior afferent fibers to the hypothalamus acting on hypothalamic opioid systems such as have been previously proposed to play a role in ECS-induced amnesia.
在完整大鼠、双侧背穹窿手术横断的大鼠、下丘脑前或后去传入神经支配的大鼠以及假手术动物中，研究了训练后即刻经角膜电惊厥休克（ECS，15.0毫安，60赫兹，2秒）对跳台抑制性回避学习（0.5毫安，60赫兹训练电击）的遗忘效应。训练后24小时对动物进行记忆保持测试。除下丘脑后部损伤组外，在所有组中均观察到了ECS的遗忘效应。穹窿损伤的动物表现出中度的记忆保持缺陷，而ECS处理使其显著恶化。结果表明，ECS的遗忘效应需要下丘脑后部通路的完整性。一种可能性是，ECS的遗忘效应可能由下丘脑后部传入纤维介导，作用于下丘脑阿片系统，如先前提出的在ECS诱导的失忆中起作用的系统。
