Lomax P, Bajorek J G, Bajorek T A, Chaffee R R
Eur J Pharmacol. 1981 May 22;71(4):483-7. doi: 10.1016/0014-2999(81)90193-x.
The mechanisms underlying the hypothermic effect of ethanol have been investigated in rats. At an ambient temperature of 26 degrees C, at which tail skin blood flow will normally be expected to play a role in regulating core temperature, no change in tail cutaneous temperature occurred during the period in which the core temperature was falling after administration of ethanol. As the drug effect waned tail skin temperature fell below the initial temperature as the hypothermia was corrected. This last observation confirms earlier results indicating a shift in the thermoregulatory set point after administration of ethanol. There was no significant change in oxygen consumption related to the ethanol induced fall in core temperature so decreased heat production would not appear to be a factor in the thermal imbalance. Neither was there any change in respiratory rate or minute volume to account for an increase in convective or evaporative heat loss via the lungs. From these results it is not clear by what mechanism the ethanol induced lowering of the set point leads to a fall in core temperature. Other avenues of heat loss, for example from other cutaneous surfaces, and further detailed thermal balance studies will be needed to resolve this problem.
已在大鼠中研究了乙醇产生低温效应的机制。在环境温度为26摄氏度时，通常预计尾部皮肤血流会在调节核心体温中发挥作用，在给予乙醇后核心体温下降期间，尾部皮肤温度没有变化。随着药物作用减弱，随着体温过低得到纠正，尾部皮肤温度降至初始温度以下。这最后一项观察结果证实了早期的结果，表明给予乙醇后体温调节设定点发生了变化。与乙醇引起的核心体温下降相关的耗氧量没有显著变化，因此产热减少似乎不是热失衡的一个因素。呼吸频率或分钟通气量也没有任何变化，以解释通过肺部对流或蒸发散热的增加。从这些结果尚不清楚乙醇引起的设定点降低通过何种机制导致核心体温下降。需要研究其他散热途径，例如来自其他皮肤表面的散热途径，并进行更详细的热平衡研究来解决这个问题。
