Sahley T L, Panksepp J, Zolovick A J
Eur J Pharmacol. 1981 Jun 19;72(2-3):261-4. doi: 10.1016/0014-2999(81)90283-1.
The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DBs) of acutely isolated domestic chicks. Nicotine attenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine were blocked by pretreatment with scopolamine. These results implicate muscarinic receptor participation in the control of separation-induced distress, and support the suggestion that nicotine-induced DV suppression may result from activation of behaviorally relevant muscarinic receptors via central release of acetylcholine.
研究了尼古丁、卡巴胆碱、六甲铵和东莨菪碱对急性隔离的家鸡的痛苦叫声（DVs）的影响。尼古丁可减弱痛苦叫声，而抗毒蕈碱的东莨菪碱则增加了分离诱导的痛苦叫声的频率。此外，东莨菪碱预处理可阻断尼古丁的应激减弱作用。这些结果表明毒蕈碱受体参与了对分离诱导的痛苦的控制，并支持了以下观点：尼古丁诱导的痛苦叫声抑制可能是通过乙酰胆碱的中枢释放激活行为相关的毒蕈碱受体所致。
