Glowa J R, Newman J D
Psychopharmacology (Berl). 1986;90(4):457-60. doi: 10.1007/BF00174060.
The effects of benactyzine (0.01-3.0 mg/kg) were examined on the frequency of alarm calls of squirrel monkeys in a laboratory setting. Under baseline conditions, few calls occurred, and neither saline nor a low dose (0.01 mg/kg) of benactyzine increased calling. Higher doses (0.03-3.0 mg/kg) of benactyzine significantly increased call rate (to 1-2 calls per s) in a dose-dependent manner. The rate-increasing effect of benactyzine on alarm calls appears to be related to a central antimuscarinic effect, as it could be partially blocked by 0.01 mg/kg physostigmine, completely blocked by 0.1 mg/kg physostigmine, but was not blocked at all by 0.1 mg/kg neostigmine. Neither of these cholinomimetics increased call rates when given alone. These findings show that benactyzine can increase alarm call rates in squirrel monkeys under defined laboratory conditions, and may serve as a useful pharmacological probe to study neurochemical mechanisms mediating the production of this type of vocalization. In the squirrel monkey, one such mechanism apparently involves a cholinergic substrate.
在实验室环境中，研究了苯那辛（0.01 - 3.0毫克/千克）对松鼠猴警报叫声频率的影响。在基线条件下，很少有叫声出现，生理盐水和低剂量（0.01毫克/千克）的苯那辛都不会增加叫声次数。较高剂量（0.03 - 3.0毫克/千克）的苯那辛以剂量依赖的方式显著增加了叫声频率（达到每秒1 - 2次叫声）。苯那辛对警报叫声的频率增加作用似乎与中枢抗毒蕈碱作用有关，因为它可被0.01毫克/千克的毒扁豆碱部分阻断，被0.1毫克/千克的毒扁豆碱完全阻断，但不被0.1毫克/千克的新斯的明阻断。单独给予这两种拟胆碱药时都不会增加叫声频率。这些发现表明，在特定的实验室条件下，苯那辛可增加松鼠猴的警报叫声频率，并且可能作为一种有用的药理学探针来研究介导这种发声产生的神经化学机制。在松鼠猴中，一种这样的机制显然涉及胆碱能底物。
