Wender M, Zórawski A, Adamczewska-Goncerzewicz Z, Mularek O
Exp Pathol. 1981;19(4):226-38. doi: 10.1016/s0232-1513(81)80068-0.
Porton mice were used in the experiments. Pregnant animals were injected intravenously with a single dose of ethylnitrosourea (ENU). The poison was administered at the 15th day of pregnancy. The cerebral myelin of offsprings of the intoxicated mothers was examined with respect to the fatty acid spectrum of myelin lipids. The results obtained lead to the following conclusions: The fatty acid pattern of the individual myelin lipid fractions has revealed significant differences between the normal myelin and that isolated from brains of mice that had been subjected to transplacental intoxication by ENU. Transplacental intoxication by ENU has not only a carcinogenic effect on the central nervous system, but it obviously also affects the lipid metabolism of membraneous structures of the developing brain. ENU when acting during foetal life induces the formation of deviated myelin, that differs significantly with respect to its lipid and fatty acid composition from that of normally developing animals.
实验使用了波顿小鼠。怀孕动物静脉注射单剂量的乙基亚硝基脲（ENU）。在怀孕第15天给予该毒物。对中毒母亲后代的脑髓磷脂进行了髓磷脂脂质脂肪酸谱的检查。所得结果得出以下结论：各个髓磷脂脂质组分的脂肪酸模式显示，正常髓磷脂与从经ENU经胎盘中毒的小鼠脑中分离出的髓磷脂之间存在显著差异。ENU经胎盘中毒不仅对中枢神经系统有致癌作用，而且显然还影响发育中大脑膜结构的脂质代谢。ENU在胎儿期起作用时会诱导形成异常髓磷脂，其脂质和脂肪酸组成与正常发育动物的髓磷脂有显著差异。
