Wender M, Adamczewska-Goncerzewicz Z, Mularek O, Sedzik J, Pancrac J
Exp Pathol (Jena). 1978;15(2):105-10. doi: 10.1016/s0014-4908(78)80074-x.
At day 15 of gestation pregnant mice were injected with a single intravenous dose of ethylnitrosourea (ENU) (80 mg/kg of body weight). The lipid composition of the myelin fraction isolated by means of differential centrifugation from brains of their offsprings was studied. The transplacentally intoxicated mice developed severe changes in the lipid composition of their central myelin sheaths, such as a markedly decreased galactolipid (both cerebroside and sulfatide) as well as plasmalogen contents. The results show, that besides being a well known carcinogenic agent, ENU is capable of affecting the lipid metabolism of the developing central nervous system. The resultant effect is the formation of a chemically defective myelin sheath.
在妊娠第15天，给怀孕小鼠静脉注射单次剂量的乙基亚硝基脲（ENU）（80毫克/千克体重）。研究了通过差速离心从其后代大脑中分离出的髓磷脂部分的脂质组成。经胎盘中毒的小鼠中枢髓鞘的脂质组成发生了严重变化，例如半乳糖脂（脑苷脂和硫脂）以及缩醛磷脂含量明显降低。结果表明，ENU除了是一种众所周知的致癌剂外，还能够影响发育中的中枢神经系统的脂质代谢。最终结果是形成化学缺陷的髓鞘。
