用硫唑嘌呤治疗的豚鼠的淋巴细胞反应性及秋水仙碱的体外作用。
Lymphocyte reactivity in Imuran-treated guinea-pigs and in vitro effect of colchicine.
作者信息
Milosević D, Sami I, Stanojević-Bakić N, Spuzić I
出版信息
Experientia. 1981 May 15;37(5):519-20. doi: 10.1007/BF01986173.
PMID:7250328
Abstract
Imuran treatment significantly diminished macrophage migration inhibition in immunized guinea-pigs and the percentage of E-rosette forming cells in all treated animals. 10(-6) M colchicine in vitro significantly increased the percentage of E-rosette forming cells in Imuran-treated animals. The results suggest possible alteration of the lymphocyte receptors after treatment with Imuran.
摘要
硫唑嘌呤治疗显著降低了免疫豚鼠的巨噬细胞移动抑制以及所有接受治疗动物中E花环形成细胞的百分比。体外10(-6) M秋水仙碱显著增加了接受硫唑嘌呤治疗动物中E花环形成细胞的百分比。结果表明硫唑嘌呤治疗后淋巴细胞受体可能发生了改变。
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