硫唑嘌呤和左旋咪唑对健康受试者及癌症患者玫瑰花结形成细胞的影响。
The effects of azathioprine and levamisole on rosette-forming cells of healthy subjects and cancer patients.
作者信息
Verhaegen H, De Cock W, De Cree J
出版信息
Clin Exp Immunol. 1977 Aug;29(2):311-5.
The in vitro effects of azathioprine and levamisole on the capacity of peripheral lymphocytes to form rosettes with sheep erythrocytes were studied in fifteen healthy subjects and forty-one cancer patients. Azathioprine significantly inhibited rosette formation of T lymphocytes in healthy subjects and cancer patients in remission. In contrast, azathioprine could not inhibit rosette formation of T lymphocytes in cancer patients with advanced disease. Patients with advanced tumour had also fewer rosette-forming cells (RFC) than healthy subjects. Levamisole, an anti-anergic chemotherapeutic agent, restored azathioprine-inhibited RFC in healthy subjects and in fifteen out of twenty-two cancer patients. Levamisole alone significantly enhanced low RFC in cancer patients.
在15名健康受试者和41名癌症患者中研究了硫唑嘌呤和左旋咪唑对外周淋巴细胞与绵羊红细胞形成玫瑰花结能力的体外影响。硫唑嘌呤显著抑制健康受试者和缓解期癌症患者中T淋巴细胞的玫瑰花结形成。相比之下，硫唑嘌呤不能抑制晚期癌症患者中T淋巴细胞的玫瑰花结形成。晚期肿瘤患者的玫瑰花结形成细胞（RFC）也比健康受试者少。左旋咪唑是一种抗无反应性化疗药物，可恢复健康受试者和22名癌症患者中22分之15的患者被硫唑嘌呤抑制的RFC。单独使用左旋咪唑可显著提高癌症患者中较低的RFC。
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