Schultz-Ehrenburg U, Lämmer D
Dermatologica. 1981;162(5):350-61.
A primary B-cell lymphoma of the skin is described, showing the clinical picture of a lymphadenosis cutis circumscripta. According to the Kiel classification, it has been classified as a centrocytic lymphoma (centrocytoma) belonging to the low-grade malignancy group. The centrocytoma is a newly defined type of lymphoma which is not identical with any earlier entity of lymphoreticular neoplasia. Although the centrocytoma is said to occur relatively often in the skin, the present case report seems to be the first clinical description of this variant. In our patient a solitary tumor of the face was found, which had slowly enlarged since 3 1/2 years. No lymph node and no systemic involvement were detectable. With a telecobalt-60 treatment up to a total of 40 Gy (= 4,000 rad) a complete involution could be achieved without recurrence 6 months after radiotherapy had been finished. In contrast to the centrocytoma of lymphonodal origin, the primary cutaneous type may obviously remain localized for a long time with low tendency to progression.
本文描述了一例原发性皮肤B细胞淋巴瘤，其临床表现为局限性皮肤淋巴组织增生。根据 Kiel 分类，它被归类为属于低级别恶性组的中心细胞淋巴瘤（中心细胞瘤）。中心细胞瘤是一种新定义的淋巴瘤类型，与任何早期的淋巴网状细胞瘤实体都不相同。尽管据说中心细胞瘤在皮肤中相对常见，但本病例报告似乎是这种变体的首例临床描述。在我们的患者中，发现面部有一个孤立性肿瘤，自3年半以来逐渐增大。未检测到淋巴结及全身受累。通过钴 -60 远距离治疗，总剂量达40 Gy（= 4000 拉德），放疗结束6个月后可实现完全消退且无复发。与淋巴结起源的中心细胞瘤不同，原发性皮肤型可能明显长时间局限，进展倾向较低。
