Kao W, Strike D P
Prostaglandins. 1978 Sep;16(3):467-71. doi: 10.1016/0090-6980(78)90226-5.
This article describes the preparation of (+)-11-deoxy-15-ethynyl prostaglandins (1 & 16). The key step involves a conjugate addition of the substituted 1-lithio-1-oct-1-ene (2) to the cyclopentenone (3 & 12) to furnish 11-deoxy-prostaglandin skeleton in a simple fashion. Of particular interest in this synthesis is the preparation of alkyl side chain (7) which was achieved in an efficient three-step synthesis starting from the readily available beta-iodo vinyl ketone (4).
本文描述了（+）-11-脱氧-15-乙炔基前列腺素（1和16）的制备。关键步骤包括将取代的1-锂代-1-辛-1-烯（2）与环戊烯酮（3和12）进行共轭加成，以简单的方式提供11-脱氧前列腺素骨架。在该合成中特别令人感兴趣的是烷基侧链（7）的制备，它是从容易获得的β-碘代乙烯基酮（4）开始通过高效的三步合成实现的。
