前列腺素及其类似物。14. 外消旋-16,16-三亚甲基前列腺素的合成及支气管扩张活性
Prostaglandins and congeners. 14. Synthesis and bronchodilator activity of dl-16,16-trimethyleneprostaglandins.
作者信息
Skotnicki J S, Schaub R E, Weiss M J
出版信息
J Med Chem. 1977 Aug;20(8):1042-7. doi: 10.1021/jm00218a010.
PMID:894672
Abstract
The interesting bronchodilator activity of novel dl-16,16-trimethyleneprostaglandin congeners and their preparation via the conjugate addition of the appropriate vinyl lithiocuprate reagent to several cyclopentenones are described. Also discussed is the preparation of the key intermediate vinyl iodine 7.
摘要
本文描述了新型dl-16,16-三亚甲基前列腺素类似物有趣的支气管扩张活性，以及通过合适的乙烯基锂铜试剂与几种环戊烯酮进行共轭加成来制备它们的方法。还讨论了关键中间体乙烯基碘7的制备。
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