Vig B K
Hum Genet. 1981;57(3):247-52. doi: 10.1007/BF00278937.
Mitotic chromosomes from human peripheral lymphocytes studied at the junction of metaphase and anaphase show that the centromeres of various chromosomes separate in a nonrandom, apparently genetically controlled sequence. It does not depend upon the position of the centromere in the chromosome, the length of the chromosome or total amount of detectable C-chromatin. In man, several chromosomes e.g. 18, 17, 2, separate very early. Such "early" cells do not include nos. 1, 13, 14, 15, and Y and very rarely nos. 21 and 22. The last separating chromosomes are those from group D, G, no. 1, 16, and Y. The possible implication of these findings in evolution, non-disjunction and the control of centromere separation sequences is discussed.
对处于中期和后期交界处的人类外周血淋巴细胞有丝分裂染色体的研究表明，各种染色体的着丝粒以非随机、明显受基因控制的顺序分离。这并不取决于着丝粒在染色体中的位置、染色体的长度或可检测到的C-染色质总量。在人类中，几条染色体，如18号、17号、2号，分离得非常早。这样的“早期”细胞不包括1号、13号、14号、15号和Y染色体，21号和22号染色体也非常罕见。最后分离的染色体是来自D组、G组的1号、16号和Y染色体。讨论了这些发现对进化、不分离现象和着丝粒分离顺序控制的可能影响。
