Walsh G A, Richards K L, Douglas S D, Blumenthal M N
J Clin Microbiol. 1981 Jun;13(6):1046-8. doi: 10.1128/jcm.13.6.1046-1048.1981.
Sera from 56 patient and normal adults were examined to quantitate total immunoglobulin E (IgE) and IgE antibodies to Staphylococcus aureus and Staphylococcus epidermidis. Patients were divided into six groups based on clinical symptoms; a seventh group consisted of normal adults. Anti-S, aureus IgE binding was significantly higher in three groups of patients (those with eczema, those with or without series staphylococcal abscesses, and allergic patients with staphylococcal skin infections) than it was in the control group. Patients with high IgE due to allergies or parasitic infections without staphylococcal infections and patients with low or normal IgE and serious staphylococcal infection showed low levels of binding. The assay measured specific binding of IgE to bacterial antigens.
检测了56例患者和正常成年人的血清，以定量总免疫球蛋白E（IgE）以及针对金黄色葡萄球菌和表皮葡萄球菌的IgE抗体。根据临床症状将患者分为六组；第七组为正常成年人。三组患者（患有湿疹的患者、有或无系列葡萄球菌脓肿的患者以及患有葡萄球菌皮肤感染的过敏患者）的抗金黄色葡萄球菌IgE结合显著高于对照组。因过敏或寄生虫感染而IgE水平高但无葡萄球菌感染的患者以及IgE水平低或正常但有严重葡萄球菌感染的患者显示出低水平的结合。该检测方法测定了IgE与细菌抗原的特异性结合。
