Rogge J L, Hanifin J M
Arch Dermatol. 1976 Oct;112(10):1391-6.
Various reports have indicated assorted immune defects in atopic dermatitis, but the prevalence and degree of the defects remain unclear. We assessed various immunological factors in 14 patients with atopic dermatitis to determine whether immunodeficiencies were present consistently and were reflected by the patients' clinical characteristics. A high incidence of cutaneous infection was noted. Cutaneous delayed-hypersensitivity testing showed anergy in eight (67%) patients. Only the seven patients with the most severe condition showed altered leukocyte function, as determined by polymorphonuclear and mononuclear leukocyte chemotaxis and by lymphocyte responsiveness to phytohemaglutinin. All three cell types where shown to be simultaneously dysfunctional during severe atopic flares. Chemotactic studies during clinical remissions disclosed notable improvement in cell migration. Serum IgE levels were elevated in each patient, but did not correlate with the degree of cutaneous anergy or altered leukocyte function.
各种报告表明特应性皮炎存在多种免疫缺陷，但这些缺陷的发生率和程度仍不明确。我们评估了14例特应性皮炎患者的多种免疫因素，以确定免疫缺陷是否持续存在，并是否由患者的临床特征反映出来。发现皮肤感染的发生率很高。皮肤迟发型超敏反应测试显示8例（67%）患者无反应。只有病情最严重的7例患者显示白细胞功能改变，这是通过多形核白细胞和单核白细胞趋化性以及淋巴细胞对植物血凝素的反应性来确定的。在严重的特应性发作期间，所有三种细胞类型均显示同时功能失调。临床缓解期的趋化性研究表明细胞迁移有显著改善。每位患者的血清IgE水平均升高，但与皮肤无反应程度或白细胞功能改变无关。
