胎儿组织能够合成一种胎盘激素。人胎儿肾脏合成绒毛膜促性腺激素β亚基的证据。
Fetal tissue can synthesize a placental hormone. Evidence for chorionic gonadotropin beta-subunit synthesis by human fetal kidney.
作者信息
McGregor W G, Raymoure W J, Kuhn R W, Jaffe R B
出版信息
J Clin Invest. 1981 Jul;68(1):306-9. doi: 10.1172/jci110249.
Abstract
Metabolically active tissues from second trimester human fetuses were examined for their ability to synthesize the placental hormones chorionic gonadotropin and chorionic somatomammotropin. During short-term incubation studies both placenta and fetal kidney were found to synthesize and secrete the beta-subunit of chorionic gonadotropin, whereas its synthesis was not observed in fetal liver, lung or muscle. In addition, chorionic somatomammotropin synthesis and secretion was demonstrated with placental tissue but could not be detected in any of the fetal tissues examined. These observations constitute the first evidence that the genome of a fetal tissue directs the synthesis of what is considered a placental hormone.
摘要
对妊娠中期人类胎儿的代谢活跃组织进行了检查，以评估它们合成胎盘激素绒毛膜促性腺激素和绒毛膜生长催乳素的能力。在短期培养研究中，发现胎盘和胎儿肾脏都能合成并分泌绒毛膜促性腺激素的β亚基，而在胎儿肝脏、肺或肌肉中未观察到其合成。此外，胎盘组织显示出绒毛膜生长催乳素的合成和分泌，但在所检查的任何胎儿组织中均未检测到。这些观察结果首次证明，胎儿组织的基因组可指导合成被认为是胎盘激素的物质。
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