Basich J E, Graves T S, Baz M N, Scanlon G, Hoffmann R G, Patterson R, Fink J N
J Allergy Clin Immunol. 1981 Aug;68(2):98-102. doi: 10.1016/0091-6749(81)90165-2.
Forty-two corticosteroid-dependent asthmatics were studied to determine whether their underlying disease might be allergic bronchopulmonary aspergillosis (ABPA). The clinical and laboratory characteristics studied included age, sex, atopic status, mean corticosteroid doses, skin tests to Aspergillus fumigatus (Af), precipitins to Af, total serum IgE, and chest roentgenograms. Twelve patients had four or more of the seven primary criteria used and were considered as the ABPA suspect group. Further studies identified three patients who were considered to have definite ABPA and an additional three patients with probable ABPA. This study suggests that previously undiagnosed ABPA can be detected in populations of corticosteroid dependent asthmatics. Corticosteroid therapy may mask ABPA, and serial evaluations of these patients may be of value in detecting additional cases of the disease.
对42名依赖皮质类固醇的哮喘患者进行了研究，以确定其潜在疾病是否可能为变应性支气管肺曲霉菌病（ABPA）。所研究的临床和实验室特征包括年龄、性别、特应性状态、皮质类固醇平均剂量、烟曲霉菌（Af）皮肤试验、Af沉淀素、血清总IgE以及胸部X线片。12名患者具备所采用的7项主要标准中的4项或更多项，被视为ABPA疑似组。进一步研究确定了3名被认为患有确诊ABPA的患者以及另外3名可能患有ABPA的患者。这项研究表明，在依赖皮质类固醇的哮喘患者群体中可以检测出先前未被诊断的ABPA。皮质类固醇治疗可能会掩盖ABPA，对这些患者进行系列评估可能有助于发现该疾病的更多病例。
