Anderson R J, Hart G R, Crumpler C P, Reed W G, Matthews C A
JAMA. 1981 Aug 21;246(8):848-50.
The response to oral clonidine hydrochloride loading in 36 severely hypertensive patients is presented. Each patient initially received 0.2 mg of clonidine hydrochloride, followed by 0.1 mg each hour until a dose of 0.7 mg had been given, or the diastolic blood pressure (BP) reached a predetermined goal (110 mm Hg or total fall of at least 20 mm Hg). Only two patients (6%) failed to reach this goal. Supine BP in the group fell from 212 +/- 22 (SD)/139 +/- 11 (SD) mm Hg to 151 +/- 21 (SD) mm Hg at six hours. The average dose of clonidine required was 0.45 mg and control was maximized at five hours. The response to oral clonidine loading in the individual patient was not predictive of the eventual dose of clonidine necessary to achieve acceptable BP control at two weeks. Oral clonidine loading is safe and effective in the management of "hypertensive urgencies" and offers several advantages over parenteral antihypertensive agents in this clinical situation.
本文介绍了36例重度高血压患者口服可乐定负荷试验的反应。每位患者最初服用0.2mg盐酸可乐定，随后每小时服用0.1mg，直至服用剂量达到0.7mg，或舒张压（BP）达到预定目标（110mmHg或至少下降20mmHg）。只有两名患者（6%）未达到该目标。该组患者仰卧位血压在6小时时从212±22（标准差）/（139±11（标准差）mmHg降至151±21（标准差）mmHg。所需可乐定的平均剂量为0.45mg，血压控制在5小时时达到最佳效果。个体患者口服可乐定负荷试验的反应并不能预测两周时实现可接受血压控制所需的最终可乐定剂量。口服可乐定负荷试验在“高血压急症”的治疗中安全有效，在此临床情况下比胃肠外降压药物具有多个优势。
