Costa J L, Murphy D L, Smith M A
Res Commun Chem Pathol Pharmacol. 1978 Oct;22(1):27-36.
In the absence of appreciable dense-body release from platelets, X537A causes rapid movement of 90--95% of vesicular H3-5HT into the extracellular medium. X537A can in addition transport to the extracellular medium 20% of the total tryptamine sequestered in platelets. Investigation of the extraction of aqueous 5HT and tryptamine into a chloroform phase, and the subsequent extraction of each of the two amines from a chloroform to an aqueous phase, suggest that 5HT, but not tryptamine, is transported efficiently between aqueous phases through a non-polar solvent. The observed differences in the movement of the two amines through platelet membranes may be attributable to a similar phenomenon.
在血小板没有明显致密体释放的情况下，X537A可使90% - 95%的囊泡型H3 - 5羟色胺快速转运到细胞外介质中。此外，X537A还可将血小板中储存的总色胺的20%转运到细胞外介质中。对水相中的5羟色胺和色胺萃取到氯仿相，以及随后将两种胺分别从氯仿相萃取到水相的研究表明，5羟色胺而非色胺可通过非极性溶剂在水相之间高效转运。观察到的两种胺通过血小板膜的转运差异可能归因于类似现象。
