Pihl E, Hughes E S, McDermott F T, Milne B J, Price A B
J Surg Oncol. 1981;16(4):333-41. doi: 10.1002/jso.2930160406.
Recurrence data from a series of 1,315 colorectal cancer patients managed by one surgeon with potentially curative resection are presented. Complete follow-up information was available on 1,287 (98%) patients. At the time of the last recurrences, 164 and 232 months for rectal and colonic tumours respectively, the long-time recurrence rate was significantly (P = 0.001) higher for rectal tumours (42%) than for colonic (33%). Although local recurrences tended to be more common in rectal than in colonic tumours (18% compared to 15%), only those in contiguity with the operative area were significantly (P less than 0.005) more common in rectal tumours. Systemic recurrences were also significantly (P less than 0.025) commoner for rectal tumours. The greater recurrence rates in rectal tumours were associated with significantly (P less than 0.001) higher incidence of stage C tumours shorter recurrence-free survival in rectal stage C tumours (P = 0.001) and higher incidence of pulmonary metastases (P less than 0.001).
本文呈现了由一位外科医生进行潜在根治性切除治疗的1315例结直肠癌患者的复发数据。1287例（98%）患者有完整的随访信息。在最后一次复发时，直肠癌和结肠癌分别为164个月和232个月，直肠癌的长期复发率（42%）显著高于结肠癌（33%）（P = 0.001）。虽然局部复发在直肠癌中比在结肠癌中更常见（分别为18%和15%），但只有与手术区域相邻的局部复发在直肠癌中显著更常见（P < 0.005）。全身复发在直肠癌中也显著更常见（P < 0.025）。直肠癌较高的复发率与C期肿瘤的发生率显著更高（P < 0.001）、直肠癌C期肿瘤的无复发生存期更短（P = 0.001）以及肺转移的发生率更高（P < 0.001）相关。
