Akusjärvi G, Persson H
Nature. 1981 Jul 30;292(5822):420-6. doi: 10.1038/292420a0.
The major late adenovirus promoter is active early after infection, selectively producing messenger RNAs coding for polypeptides with molecular weights of 55,000, 52,000 and 14,000. This selective expression suggests that a differential splicing pattern occurs at the transition from early to late viral gene expression. Activation of the late promoter and splicing of the 55, 52K mRNAs does not require newly synthesized virus polypeptides.
腺病毒主要晚期启动子在感染后早期即具有活性，选择性地产生编码分子量为55,000、52,000和14,000的多肽的信使核糖核酸。这种选择性表达表明，在从病毒早期基因表达向晚期基因表达的转变过程中发生了差异剪接模式。晚期启动子的激活以及55K、52K信使核糖核酸的剪接并不需要新合成的病毒多肽。
