George B, Landau-Ferey J, Benoit O, Dondey M, Cophignon J
Neurochirurgie. 1981;27(1):35-8.
In 16 young (15 to 25 years) patients, sleep recordings have been performed one month (group T1, 10 cases) or 6 months (group T6,6 cases) after recovery of consciousness following severe head injury. Group T1 can be divided in two subgroups according to clinical and EEG datas: T1A (4 cases) with long duration of coma (15 to 40 days) and low level of brain stem dysfunction (diencephalic). In group T6 every duration of coma and level of dysfunction are present. Percentage of intrasleep wakefulness and number of awakenings are very increased in group T1A (31,5% and 24); these datas are less increased in group T1B (10,1% and 19) and T6 (11.8% and 19). Percentage of REM sleep is very low in group T1A (9,57%) and T1B (12,65%) because of short duration of each phase. In group T6 REM sleep is close to control subjects (16,15% and 20,52%). These results are compared to those reported in normal or insomniac subjects of same age or much older. They are very similar to sleep perturbations observed in elderly (70 years) but normal people. This may evoke an early ageing of brain stem structures involved in organization of wakefulness-sleep rhythm and REM sleep.
在16名年轻（15至25岁）患者中，于重度颅脑损伤后意识恢复1个月（T1组，10例）或6个月（T6组，6例）时进行了睡眠记录。根据临床和脑电图数据，T1组可分为两个亚组：T1A（4例）昏迷持续时间长（15至40天）且脑干功能障碍程度低（间脑）。T6组中各种昏迷持续时间和功能障碍程度均有。T1A组睡眠中觉醒百分比和觉醒次数显著增加（分别为31.5%和24次）；T1B组（分别为10.1%和19次）和T6组（分别为11.8%和19次）增加幅度较小。由于每个阶段持续时间短，T1A组和T1B组快速眼动睡眠百分比非常低（分别为9.57%和12.65%）。T6组快速眼动睡眠接近对照组（分别为16.15%和20.52%）。将这些结果与同年龄或年龄大得多的正常或失眠受试者的结果进行比较。它们与70岁正常老年人中观察到的睡眠紊乱非常相似。这可能引发参与觉醒-睡眠节律和快速眼动睡眠组织的脑干结构过早老化。
