Bhargava V K, Bhargava P, Sharma D N, Tripathi K D
Neurosci Lett. 1981 May 6;23(2):175-9. doi: 10.1016/0304-3940(81)90036-7.
Intravenous infusion of strychnine or D-tubocurarine chloride attenuated the cardiac depressant action and fall in blood pressure produced by electrical stimulation of the right vagus nerve in dogs anesthesized with pentobarbitone sodium. The effects of exogenous acetylcholine on the heart and blood pressure (B.P.) were not modified by strychnine or D-turbocurarine. Physostigmine sulphate potentiated the effects of injected acetylcholine without modifying the effects of strychnine and D-tubocurarine on vagal transmission. Dimethylphenylpiperazinium bromide also produced its characteristic effects on the heart and B.P. in the presence of strychnine and D-tubocurarine. The results indicate that strychnine and D-tubocurarine inhibition of vagal transmission is not a result of blockade of peripheral cholinergic receptors or cardiac vagal ganglia. This inhibition occurs presumably via a preganglionic presynaptic action.
静脉注射士的宁或氯化筒箭毒碱可减弱戊巴比妥钠麻醉犬电刺激右侧迷走神经所产生的心脏抑制作用和血压下降。士的宁或氯化筒箭毒碱对外源性乙酰胆碱对心脏和血压的作用无影响。硫酸毒扁豆碱可增强注射乙酰胆碱的作用，但不改变士的宁和氯化筒箭毒碱对迷走神经传递的作用。在士的宁和氯化筒箭毒碱存在的情况下，溴化二甲基苯基哌嗪对心脏和血压也产生其特征性作用。结果表明，士的宁和氯化筒箭毒碱对迷走神经传递的抑制不是外周胆碱能受体或心脏迷走神经节阻断的结果。这种抑制可能是通过节前突触前作用发生的。
