Loud F B, Froberg D, Reichardt J, Holst J J, Rehfeld J F, Christiansen J
Scand J Gastroenterol. 1978;13(7):795-8. doi: 10.3109/00365527809182193.
The effect of intravenous infusion of glucagon (300 ng x kg(-1) x h(-1)), 1-arginine (0.6 g x kg(-1) x h(-1)) and of saline on meal-stimulated gastric acid secretion was studied in six healthy volunteers. Infusion of glucagon and 1-arginine enhanced plasma concentrations of pancreatic glucagon to 65--85 pmol/l, a level similar to that seen after a normal protein-rich meal. Both infusions significantly inhibited the acid response to the meal, most pronounced after 1-arginine. The difference in acid inhibition could not be ascribed either to differences in plasma glucagon concentrations or to differences in serum gastrin concentrations. The study supports the concept that pancreatic glucagon is a physiological inhibitor of gastric acid secretion.
在六名健康志愿者中研究了静脉输注胰高血糖素（300 ng·kg⁻¹·h⁻¹）、L-精氨酸（0.6 g·kg⁻¹·h⁻¹）和生理盐水对进餐刺激的胃酸分泌的影响。输注胰高血糖素和L-精氨酸可使血浆胰高血糖素浓度升高至65 - 85 pmol/L，这一水平与正常富含蛋白质的餐后所见水平相似。两种输注均显著抑制了对进餐的酸反应，以L-精氨酸输注后最为明显。酸抑制的差异既不能归因于血浆胰高血糖素浓度的差异，也不能归因于血清胃泌素浓度的差异。该研究支持胰高血糖素是胃酸分泌的生理抑制剂这一概念。
