Culture of nervous tissue from rats of various age for some pharmacological studies.

Explants of nervous tissue from locus coeruleus of rats 30-40 days old grow in the tissue culture similarly well as the explants from embryos or newborn rats under the same culture conditions. This material may be employed particularly for investigation of the action of drugs on central monaoaminergic process, as after the 30th day of the postnatal life essential monoaminergic mechanisms in the brain are already fully developed, and endogenous noradrenaline is present in the neural cells.