Graczyk J
Pol J Pharmacol Pharm. 1981 Jan-Feb;33(1):73-80.
The toxicity of methotrexate and cyclophosphamide determined by LD50 was depressed in the early period of development of sarcoma Sa-180. In the late period of development of Sa-180 and in mice with leukemia L-1210 the toxicity was higher than in healthy mice. The growth of transplantable neoplasms leads to cachexia, hypoproteinemia and dysproteinemia.
通过半数致死量（LD50）测定，甲氨蝶呤和环磷酰胺在肉瘤Sa - 180发育早期的毒性降低。在肉瘤Sa - 180发育后期以及患有白血病L - 1210的小鼠中，毒性高于健康小鼠。可移植肿瘤的生长会导致恶病质、低蛋白血症和蛋白异常血症。
