Goldman J M, Seitanides B, Ruutu T, Th'ng K H
Scand J Haematol. 1978 Oct;21(4):318-22. doi: 10.1111/j.1600-0609.1978.tb00372.x.
Granulocyte-committed progenitor cells (colony-forming units, CFUc) in the blood of 10 patients with primary myelosclerosis and 2 patients with myelosclerosis following polycythaemia vera were assayed by the agar culture technique. The mean number of CFUc was 54.1 +/- 109 (SD) (range 1.4--394) x 10(6)/1 which corresponded to an increase of more than 1000-fold above normal levels. There was a linear relationship of CFUc with total leucocyte count in the different patients. The magnitude of this increase resembles that found in untreated patients with chronic granulocytic leukaemia and is therefore in keeping with the concept that the concentration of CFUc in the circulation is due to a primary increase in their number and not to disordered release from the marrow.
采用琼脂培养技术对10例原发性骨髓纤维化患者及2例真性红细胞增多症后骨髓纤维化患者血液中的粒细胞定向祖细胞（集落形成单位，CFUc）进行了检测。CFUc的平均数量为54.1±109（标准差）（范围1.4 - 394）×10⁶/升，这相当于比正常水平增加了1000倍以上。不同患者的CFUc与白细胞总数呈线性关系。这种增加的幅度与未经治疗的慢性粒细胞白血病患者相似，因此符合循环中CFUc浓度是由于其数量原发性增加而非骨髓释放紊乱的概念。
