Standen G, Philip M A, Fletcher J
Br J Haematol. 1979 Jul;42(3):417-23. doi: 10.1111/j.1365-2141.1979.tb01150.x.
The number of granulocytic progenitor cells (colony forming units in culture: CFUc) in the blood of patients with Down's syndrome was found to be reduced by 73.2% when compared to a group of age and sex matched controls. However, the blood CFUc of the Down's syndrome patients and the controls showed similar sensitivity to hydroxyurea which suggests that the low number of progenitor cells in Down's syndrome is not compensated by a marked increase in their cellular proliferation. The colony size distributions were similar for both the patients and the controls and, in addition, repeated assays at various intervals revealed no marked fluctuation in the number of blood CFUc in either group. The significance of the reduced number of circulating CFUc in Down's syndrome in relation to the known susceptibility of such patients to leukaemia is discussed.
与一组年龄和性别匹配的对照组相比，发现唐氏综合征患者血液中的粒细胞祖细胞（培养中的集落形成单位：CFUc）数量减少了73.2%。然而，唐氏综合征患者和对照组的血液CFUc对羟基脲表现出相似的敏感性，这表明唐氏综合征患者祖细胞数量低并没有因细胞增殖的显著增加而得到补偿。患者和对照组的集落大小分布相似，此外，在不同时间间隔进行的重复检测显示，两组的血液CFUc数量均无明显波动。文中讨论了唐氏综合征患者循环CFUc数量减少与这类患者已知的白血病易感性之间的关系。
