Draenert Y, Draenert K
Scan Electron Microsc. 1980(4):103-11.
Standard-sized holes were drilled in the tibia of rats resulting in a reproducible model which can be used to study the different stages of gap healing where practically no influence from biomechanical forces is present. Primary bone healing takes place in holes up to a diameter of 800 micrometer. In this case, no differentiated cartilage or connective tissue is formed. The medullary cavity is closed by a sealing callus. The bony splinters resulting from the operation are incorporated into the osseous framework. Revascularization results from the formation of medullary sinus which grows into the hole. The periosteal osseous depositions are supplied by the nutrient vessels, too. The centrifugal arterial bloodstream and the centripetal venous backflow are maintained under stress conditions during gap healing. Our investigations showed that after ten days drill holes in compact bone had been two-thirds filled from the medullary canal. At this point, the periosteal new bone formation had not yet reached the edge of the hole. The medullary sinus system in the medullary canal is different from the periosteal vascular network in that the former displays vessels with a regularly developed framework.
在大鼠胫骨上钻出标准尺寸的孔，形成一种可重复的模型，该模型可用于研究间隙愈合的不同阶段，在此阶段几乎不存在生物力学力的影响。直径达800微米的孔内发生一期骨愈合。在这种情况下，不会形成分化的软骨或结缔组织。髓腔由封闭性骨痂封闭。手术产生的骨碎片融入骨框架。髓窦形成导致血管再生，髓窦向孔内生长。骨膜骨沉积也由营养血管供应。在间隙愈合过程中的应激条件下，离心动脉血流和向心静脉回流得以维持。我们的研究表明，十天后，密质骨中的钻孔已从髓腔填充了三分之二。此时，骨膜新骨形成尚未到达孔的边缘。髓腔内的髓窦系统与骨膜血管网络不同，前者显示出具有规则发育框架的血管。
