Ooshima A
Science. 1981 Aug 7;213(4508):666-8. doi: 10.1126/science.7256267.
In a study of human atherosclerotic plaques, the relative abundance of alpha chains in pepsin-solubilized collagens from 28 human aortas was estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The ratio of alpha B, a component of the alpha chain in type V collagen, to alpha 1(I) was markedly increased in the atherosclerotic plaques compared to the nonsclerotic intact media and adventitia. It is suggested that proliferating smooth muscle cells in the sclerotic lesion were transformed to synthesize a larger amount of collagen alpha B chain during the process of human atherogenesis.
在一项关于人类动脉粥样硬化斑块的研究中，通过十二烷基硫酸钠 - 聚丙烯酰胺凝胶电泳法，对来自28个人主动脉的胃蛋白酶可溶解胶原蛋白中的α链相对丰度进行了估计。与非硬化的完整中膜和外膜相比，V型胶原蛋白α链的一个组分αB与α1(I)的比率在动脉粥样硬化斑块中显著增加。这表明在人类动脉粥样硬化形成过程中，硬化病变中增殖的平滑肌细胞发生转化，以合成大量的胶原蛋白αB链。
