Gibson G E, Peterson C, Jenden D J
Science. 1981 Aug 7;213(4508):674-6. doi: 10.1126/science.7256270.
The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of senescent mice. The incorporation of [U-14C]glucose into acetylcholine decreased in both strains by 40 +/- 4 per cent in 10-month-old mice and by 58 +/- 9 percent in 30-month-old mice compared with mice 3 months old. The incorporation of [2H4]choline into acetylcholine declined 60 and 73 percent in 10- and 30-month-old mice, respectively. Deficits in the cholinergic system may contribute to brain dysfunctions that complicate senescence.
在两种衰老小鼠品系（C57BL和BALB/c）中，全脑乙酰胆碱的合成减少。与3个月大的小鼠相比，[U-14C]葡萄糖掺入乙酰胆碱的量在10个月大的小鼠中，两种品系均下降了40±4%，在30个月大的小鼠中下降了58±9%。[2H4]胆碱掺入乙酰胆碱的量在10个月和30个月大的小鼠中分别下降了60%和73%。胆碱能系统的缺陷可能导致使衰老复杂化的脑功能障碍。
