Danis V A, Harries A D, Heatley R V
Clin Exp Immunol. 1984 Apr;56(1):159-66.
Intestinal mucosal immunoglobulin secretion in vitro has been studied by culture of endoscopic biopsy tissues obtained from various sites along the gastrointestinal tract. IgA and IgM were the predominant immunoglobulins produced by intestinal tissues distal to the stomach and secretion of both reached a maximum in the small intestine of normal individuals. In patients with inflammatory bowel disease, characteristic alterations in immunoglobulin production were observed in cultures of large intestinal tissue. In ulcerative colitis (UC), significant reductions in IgA secretion (P less than 0.03) occurred in the rectum during remission and IgM in the colon in active disease (P less than 0.01). However, in active Crohn's disease (CD), rectal IgM secretion was enhanced (P less than 0.004) and IgA diminished (P less than 0.01). IgG secretion was increased throughout the colon in UC especially in distal sites, due largely to significant increases in pre-formed immunoglobulin (P less than 0.02). Similar total increases were observed in colonic tissues from patients with CD, although IgG synthesis in biopsies from rectal sites was normal. These findings suggest that specific abnormalities of intestinal mucosal immunoglobulin synthesis occur in patients with both UC and CD.
通过培养从胃肠道不同部位获取的内镜活检组织，对体外肠道黏膜免疫球蛋白分泌进行了研究。IgA和IgM是胃远端肠道组织产生的主要免疫球蛋白，在正常个体的小肠中两者的分泌均达到最大值。在炎症性肠病患者中，大肠组织培养物中观察到免疫球蛋白产生的特征性改变。在溃疡性结肠炎（UC）患者中，缓解期直肠IgA分泌显著减少（P<0.03），活动期结肠IgM分泌显著减少（P<0.01）。然而，在活动期克罗恩病（CD）患者中，直肠IgM分泌增强（P<0.004），IgA减少（P<0.01）。UC患者整个结肠的IgG分泌增加，尤其是在远端部位，这主要是由于预先形成的免疫球蛋白显著增加（P<0.02）。CD患者的结肠组织也观察到类似的总体增加，尽管直肠部位活检组织中的IgG合成正常。这些发现表明，UC和CD患者均存在肠道黏膜免疫球蛋白合成的特异性异常。
