Meyerson B J, Höglund A U
Acta Pharmacol Toxicol (Copenh). 1981 Feb;48(2):168-80. doi: 10.1111/j.1600-0773.1981.tb01604.x.
There is an increasing demand for appropriate methods for analysing the pharmacological and toxicological action of chemical agents on behavioural patterns. The present study describes a non-instrumental approach to the study of exploratory and socio-sexual behaviours in the laboratory male rat. The behaviours were differentiated in terms of latency of onset, incidence, frequency and duration. Castrated and intact males were tested under three defined test situations. One test was focused on exploratory behaviour and two tests in which the male encountered an oestrous female or a castrated male were set up to study social and sexual behaviours. A multivariate statistical method was used to analyse differences in the behavioural profiles observed in the different tests. The data show that simultaneous recording of several spontaneous behaviours may be a useful technique for investigating how a compound influences behavioural processes.
对于分析化学物质对行为模式的药理和毒理作用的适当方法的需求日益增加。本研究描述了一种用于研究实验室雄性大鼠探索行为和社会性行为的非仪器方法。这些行为根据发作潜伏期、发生率、频率和持续时间进行区分。阉割和未阉割的雄性大鼠在三种特定的测试情境下进行测试。一项测试聚焦于探索行为，另外两项测试中，雄性大鼠分别与发情期雌性大鼠或阉割雄性大鼠接触，以研究社会行为和性行为。使用多变量统计方法分析在不同测试中观察到的行为特征差异。数据表明，同时记录多种自发行为可能是研究化合物如何影响行为过程的一种有用技术。
