Schussler G C, Stimmel B, Korn F
Am J Drug Alcohol Abuse. 1980;7(3-4):379-87. doi: 10.3109/00952998008993434.
The cause of increased thyroid hormone binding in narcotic addicts has been investigated. The average T3, T4, and T3 binding ratio were all significantly higher in addicts than in controls. Free T4 and free T3 indices were normal. Those patients who had abnormally high T3 binding ratios had significantly more severe abnormalities of liver function than the other methadone-treated addicts. Together with evidence that chronic active hepatitis in the nonaddicted population is associated with increased serum thyroid hormone binding, these observations lead us to conclude that the increased serum thyroid hormone binding and total thyroid hormone concentration found in sera of narcotic addicts is due to associated liver disease.
对麻醉品成瘾者甲状腺激素结合增加的原因进行了研究。成瘾者的平均三碘甲状腺原氨酸（T3）、甲状腺素（T4）和T3结合率均显著高于对照组。游离T4和游离T3指数正常。那些T3结合率异常高的患者，其肝功能异常比其他接受美沙酮治疗的成瘾者严重得多。再加上有证据表明非成瘾人群中的慢性活动性肝炎与血清甲状腺激素结合增加有关，这些观察结果使我们得出结论，麻醉品成瘾者血清中发现的血清甲状腺激素结合和总甲状腺激素浓度增加是由相关的肝脏疾病所致。
