Iosif S, Ulmsten U
Am J Obstet Gynecol. 1981 Jul 15;140(6):645-50. doi: 10.1016/0002-9378(81)90197-6.
Twelve pregnant women were examined by urethral pressure profile measurement and simultaneous urethrocystometry early in pregnancy (weeks 12 to 16), in the thirty-eighth week, and 5 to 7 days after delivery. All patients reported symptoms of stress incontinence starting at an early 5 to 7 days after delivery. All patients reported symptoms of stress incontinence starting at an early gestational age, it was found that that the stress incontinent women, compared to 14 continent, healthy women from whom measurements were obtained earlier, had shorter urethral lengths. Furthermore, no increase in urethral length during pregnancy was registered among the stress incontinent women, whereas such an increase did occur in the continent women. In contrast to the continent women, the incontinent patients had a low urethral closure pressure at rest and this pressure did not appear to increase sufficiently to compensate for the progressive increase in bladder pressure during pregnancy. As a result the urethral closure pressure in the stress incontinent women, therefore, decreased more and more during stress situations as pregnancy progressed, resulting in an increased leakage of urine.
对12名孕妇在妊娠早期(第12至16周)、妊娠第38周以及分娩后5至7天进行了尿道压力分布测量和同步膀胱尿道测压检查。所有患者均报告在分娩后早期5至7天开始出现压力性尿失禁症状。所有患者均报告在妊娠早期就出现压力性尿失禁症状,结果发现,与14名此前进行过测量的无压力性尿失禁的健康女性相比,有压力性尿失禁的女性尿道较短。此外,有压力性尿失禁的女性在孕期尿道长度未增加,而无压力性尿失禁的女性则有增加。与无压力性尿失禁的女性不同,有压力性尿失禁的患者静息时尿道闭合压较低,且该压力似乎未充分增加以代偿孕期膀胱压力的逐渐升高。因此,随着妊娠进展,有压力性尿失禁的女性在应激情况下尿道闭合压越来越低,导致尿失禁增加。