Girgis S M, Abd el-Rahman Y, Awad H, Eisa I, Younan N, Mittawy B, el-Saleh Q A
Andrologia. 1981 Jan-Feb;13(1):16-9. doi: 10.1111/j.1439-0272.1981.tb00002.x.
To test for the theory of testicular hypoxia in subfertile males with varicocele, the testicular mean blood level of lactate and pyruvate was compared with that of a control group. Statistical analysis of data showed a lower mean of lactate and of pyruvate in the testicular vein of varicocele patients. It is concluded that in varicocele there is no accumulation of lactic acid, thus excluding testicular hypoxia. Since lactate and pyruvate mean concentrations in testicular vein were correlated, it is suggested that in cases of varicocele there is defective glycolysis preceding the stage of pyruvate formation.
为了验证精索静脉曲张导致男性不育的睾丸缺氧理论，研究人员将精索静脉曲张男性患者睾丸中的乳酸和丙酮酸平均血药浓度与对照组进行了比较。数据统计分析表明，精索静脉曲张患者睾丸静脉中的乳酸和丙酮酸平均浓度较低。研究得出结论，精索静脉曲张患者不存在乳酸堆积，因此可排除睾丸缺氧的情况。由于睾丸静脉中乳酸和丙酮酸的平均浓度具有相关性，研究人员推测，精索静脉曲张患者在丙酮酸形成阶段之前存在糖酵解缺陷。
