Sale J K, Johnstone J H
Ann Clin Biochem. 1981 Mar;18 (Pt 2):71-5. doi: 10.1177/000456328101800203.
High-density lipoprotein (HDL) cholesterol, total cholesterol, and triglyceride concentrations were measured in fasting blood samples from 74 controls and 185 patients with untreated primary hyperlipoproteinaemia. The mean HDL cholesterol levels and the total cholesterol:HDL cholesterol ratios were significantly different between male and female subjects. Only patients with Fredrickson type IV hyperlipoproteinaemia had HDL cholesterol concentrations significantly lower than controls, but all subjects with hyperlipoproteinaemia had total:HDL cholesterol ratios significantly higher than control values. Subsequent investigations were performed on 31 patients during treatment of the hyperlipoproteinaemia by diet alone or in combination with clofibrate. Responses were variable, but generally improvements in the concentrations of triglyceride and total cholesterol were accompanied by an unchanged or decreased total:HDL cholesterol ratio, although there was not necessarily an increase in the HDL cholesterol itself.
在74名对照者和185名未经治疗的原发性高脂蛋白血症患者的空腹血样中，检测了高密度脂蛋白（HDL）胆固醇、总胆固醇和甘油三酯浓度。男性和女性受试者的平均HDL胆固醇水平以及总胆固醇与HDL胆固醇的比值存在显著差异。只有弗雷德里克森IV型高脂蛋白血症患者的HDL胆固醇浓度显著低于对照者，但所有高脂蛋白血症患者的总胆固醇与HDL胆固醇比值均显著高于对照值。随后，对31名通过单纯饮食或联合氯贝丁酯治疗高脂蛋白血症的患者进行了后续研究。反应各不相同，但总体而言，甘油三酯和总胆固醇浓度的改善伴随着总胆固醇与HDL胆固醇比值不变或降低，尽管HDL胆固醇本身不一定会增加。
