Cowell D C, Taylor W H
Ann Clin Biochem. 1981 Mar;18 (Pt 2):76-83. doi: 10.1177/000456328101800204.
The serum ionic fluoride concentrations in 497 normal individuals, from areas with non-fluoridated water supplies, ranged from 0.25 to 2.20 micromol F-/1 and were positively correlated with age (r = 0.31, p less than 0.001). Distribution of the data with age, coupled with the distribution of serum calcium with age, suggests a possible change in bone metabolism between 26 and 35 years of age. Serum fluoride levels vary with the time of day with a mean minimum value at 0800 and a mean peak value at 2200. Renal clearance studies gave fluoride ion clearances ranging from 19.5 to 44.0 ml/min and tubular reabsorption of fluoride ion ranging from 61.5 to 86.5%. After oral ingestion of 0.48 mmol sodium fluoride, peak serum levels occurred at 60 to 90 minutes; the peak levels were significantly higher in women than in men.
497名来自非氟化水源地区的正常个体的血清离子氟浓度范围为0.25至2.20微摩尔F⁻/1，且与年龄呈正相关（r = 0.31，p < 0.001）。数据随年龄的分布，以及血清钙随年龄的分布，提示26至35岁之间骨代谢可能发生变化。血清氟水平随一天中的时间而变化，0800时平均最低值，2200时平均峰值。肾脏清除率研究显示氟离子清除率范围为19.5至44.0毫升/分钟，氟离子肾小管重吸收率范围为61.5至86.5%。口服0.48毫摩尔氟化钠后，血清峰值出现在60至90分钟；女性的峰值水平显著高于男性。
